ESTScan 3.0.2

  Сообщить об ошибке         Сообщить о новой версии         Дополнить описание

Описание программы ESTScan

ESTScan project is a program that can detect coding regions in DNA sequences, even if they are of low quality. ESTScan will also detect and correct sequencing errors that lead to frameshifts.
ESTScan is not a gene prediction program , nor is it an open reading frame detector. In fact, its strength lies in the fact that it does not require an open reading frame to detect a coding region. As a result, the program may miss a few translated amino acids at either the N or the C terminus, but will detect coding regions with high selectivity and sensitivity.
Method
ESTScan takes advantages of the bias in hexanucleotide usage found in coding regions relative to non-coding regions. This bias is formalized as an inhomogeneous 3-periodic fifth-order Hidden Markov Model (HMM). Additionally, the HMM of ESTScan has been extended to allows insertions and deletions when these improve the coding region statistics.

· Ключевые особенности и характеристики ESTScan 3.0.2

· Ограничения ESTScan 3.0.2

· Специальные требования ESTScan 3.0.2

· История версий и изменений ESTScan

· A bug has been found and fixed in the BTLib package.
· The bug prevented the extract_mRNA script from the estscan package from functioning properly when parsing RefSeq sequences.
· The prepare_data script has also been fixed to properly report the percent of masked nucleotides.
· All users preparing score matrices for ESTScan are strongly encouraged to update.
· Updating is less important for people who only scan sequences with already existing matrices.

· Описание и дополнения от редакторов и пользователей сайта

Связанные статьи, обзоры и новости